Vincristine, an anticancer drug, is known to induce neuronal cell damage. We have elucidated the alteration in performance of the hippocampus and cerebellum following chronic vincristine treatment 0. Intraperitoneal injection of vincristine in adolescent rats caused impairment of motor and cognitive behavior. In the probe test, the length of path traveled and percent swimming time for vincristine-treated rats in the correct quadrant was significantly less than for the saline-treated control groups. The path length and time latency at the 2nd and 3rd blocks of trials for the male vincristine-treated group was significantly higher than that for the female saline- and the vincristine-treated rats. In the rod test, vincristine exposure impaired the motor coordination in both male and female rats. Exposure to vincristine caused a significant decrease in hanging time in male rats, compared with the saline- and the vincristine-treated female rats, while there were no differences between the female vincristine-treated rats and the saline-treated rats of both sexes.
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Kristin Heslop, DMA, has gained and abandoned over a thousand pounds. A artiste by trade and training, she attended Union College in Lincoln, Nebraska. Heslop has taught at Enterprise Academy, Wichita State University, Union College, Concordia Academe, and the University of Nebraska-Lincoln, after that has performed on the flute, baby grand, harpsichord, and organ throughout the midwest. In addition to music, she derives great pleasure from political and ecological activism, creating visual art, and audible range her cat Lukas purr. Enhance your purchase. Print length. Publication date. December 16,
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